Antibody-targeted chemotherapy with immunoconjugates of calicheamicin

Curr Opin Pharmacol. 2003 Aug;3(4):386-90. doi: 10.1016/s1471-4892(03)00083-3.

Abstract

Targeted delivery of cytotoxic agents to tumours is believed to improve both their anti-tumour efficacy and their safety. Antibodies specific for tumour-associated antigens have been used to deliver cytotoxic agents to tumour cells. Calicheamicin is a potent cytotoxic agent that causes double-strand DNA breaks, resulting in cell death. When conjugated to monoclonal antibodies specific for tumour-associated antigens, calicheamicin exerts strong antigen-specific anti-tumour effects against human tumour xenografts in preclinical models. Antibody-targeted chemotherapy with immunoconjugates of calicheamicin, exemplified by gemtuzumab ozogamicin (Mylotarg), is a clinically validated therapeutic strategy for the treatment of human cancer.

Publication types

  • Review

MeSH terms

  • Aminoglycosides / chemistry
  • Aminoglycosides / pharmacology
  • Aminoglycosides / therapeutic use*
  • Animals
  • Antibodies, Monoclonal / chemistry
  • Antibodies, Monoclonal / pharmacology*
  • Antibodies, Monoclonal / therapeutic use*
  • Antibodies, Monoclonal, Humanized
  • Antigens, CD / immunology
  • Antigens, Differentiation, B-Lymphocyte / immunology
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use*
  • Cell Adhesion Molecules*
  • Clinical Trials as Topic
  • Enediynes
  • Gemtuzumab
  • Humans
  • Immunoconjugates / chemistry
  • Immunoconjugates / pharmacology
  • Immunoconjugates / therapeutic use*
  • Inotuzumab Ozogamicin
  • Lectins / immunology
  • Leukemia, Myeloid, Acute / drug therapy
  • Lymphoma, B-Cell / drug therapy
  • Sialic Acid Binding Ig-like Lectin 2

Substances

  • Aminoglycosides
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Antigens, CD
  • Antigens, Differentiation, B-Lymphocyte
  • Antineoplastic Agents
  • CD22 protein, human
  • Cell Adhesion Molecules
  • Enediynes
  • Immunoconjugates
  • Lectins
  • Sialic Acid Binding Ig-like Lectin 2
  • calicheamicin gamma(1)I
  • Gemtuzumab
  • Inotuzumab Ozogamicin