Crosstalk between glucocorticoids and mitogen-activated protein kinase signalling pathways

Curr Opin Pharmacol. 2003 Aug;3(4):404-11. doi: 10.1016/s1471-4892(03)00073-0.


Synthetic glucocorticoids are potent modulators of the immune system, and are clinically invaluable in the treatment of a wide variety of conditions. However, their use can be limited by harmful side effects, and their mechanisms of action remain poorly understood and controversial. It has recently been reported that glucocorticoids induce the expression of two genes that participate in cross-talk with the mitogen-activated protein kinase signalling pathways. It is possible that both therapeutic and harmful effects of glucocorticoids may be mediated by these genes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / immunology
  • Cell Division / immunology
  • Gene Expression Regulation
  • Glucocorticoids / pharmacology*
  • Humans
  • Inflammation / immunology
  • Inflammation / metabolism
  • Mitogen-Activated Protein Kinases / genetics
  • Mitogen-Activated Protein Kinases / immunology
  • Mitogen-Activated Protein Kinases / physiology*
  • Signal Transduction / immunology
  • Signal Transduction / physiology*
  • Transcription Factors / genetics
  • Transcription Factors / immunology
  • Transcription Factors / physiology
  • Transcription, Genetic / drug effects


  • Glucocorticoids
  • TSC22D3 protein, human
  • Transcription Factors
  • Mitogen-Activated Protein Kinases