Abstract
In view of alleged antidiabetic potential, effect of the petroleum ether, methanol, and aqueous extracts of Terminalia catappa Linn (combretaceae) fruit, on fasting blood sugar levels and serum biochemical analysis in alloxan-induced diabetic rats were investigated. All the three extracts of Terminalia catappa produced a significant antidiabetic activity at dose levels 1/5 of their lethal doses. Concurrent histological studies of the pancreas of these animals showed comparable regeneration by methanolic and aqueous extracts which were earlier, necrosed by alloxan.
MeSH terms
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Alloxan / adverse effects
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Alloxan / blood
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Animals
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Blood Glucose / drug effects
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Body Weight / drug effects
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Diabetes Mellitus, Experimental / blood
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Diabetes Mellitus, Experimental / chemically induced
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Diabetes Mellitus, Experimental / drug therapy*
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Fruit*
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Glyburide / therapeutic use
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Hypoglycemic Agents / therapeutic use*
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India
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Islets of Langerhans / drug effects
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Islets of Langerhans / pathology
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Mice
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Photomicrography
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Phytotherapy*
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Plant Extracts / therapeutic use*
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Rats
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Rats, Wistar
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Terminalia*
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Time Factors
Substances
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Blood Glucose
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Hypoglycemic Agents
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Plant Extracts
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Alloxan
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Glyburide