[Expression of inducible nitric oxide synthase in human esophageal biopsies from carcinoma and precancerous lesions]

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2000 Dec;22(6):570-2.
[Article in Chinese]


Objective: To investigate the possible role of inducible nitric oxide synthase (iNOS) in esophageal carcinogenesis.

Methods: iNOS expressions in normal epithelial cells(NC), hyperplastic cells(HC), atypical hyperplastic cells(AHC) from grade I to III, carcinoma in situ(CIS), squamous cell carcinoma(SCC), and adenocarcinoma(ADC) were detected with immunohistochemistry.

Results: The positive rates of immunohistochemistry staining was 0 for NC, 2.5% for HC, 4.0%, 7.5% and 2.5% for AHC grade I to III respectively, 1.4% for CIS, 8.5% for SCC and 71.4% for ADC.

Conclusions: There is a high expression of iNOS in human esophageal adenocarcinomas. Frequent expression of iNOS may be a potential event in ADC carcinogenesis. There is no correlation between iNOS and SCC carcinogenesis.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / enzymology*
  • Carcinoma, Squamous Cell / enzymology*
  • Esophageal Neoplasms / enzymology*
  • Humans
  • Immunohistochemistry
  • Nitric Oxide Synthase / metabolism*
  • Nitric Oxide Synthase Type II
  • Precancerous Conditions / enzymology*


  • NOS2 protein, human
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type II