[Impact of glutamine of gut permeability and clinical prognosis on the aging patients undergoing gastric-intestinal operation]

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2000 Oct;22(5):425-7.
[Article in Chinese]


Objective: To evaluate the impact of parenteral nutrition supplemented glutamine on aging patients undergoing gastric-intestinal operation.

Methods: 30 patients above 60 years old undergoing gastric-intestinal operation, a randomized double-blind protocol was designed, divided into two groups, received impact isocaloric parenteral nutrition. The study group received alanyl-glutamine [0.5 g/(kg.d)]. To observe plasma amino acids profile, nitrogen balance, intestinal permeability and clinical prognosis, examine clinical chemistry variables and observe the adverse reactions in order to find out its safety.

Results: The patients in both groups were comparable prior to the operation. The plasma glutamine level of study group is higher than the control group, it's cumulative nitrogen balance values were prior to the control group, L/M ratio was lower than the control group. The complications related to infection was observed more in the control group. No adverse reaction was observed in both groups.

Conclusions: Ala-Gln-supplemented PN improved nitrogen balance and maintained intestinal permeability, reduced complications.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cell Membrane Permeability / drug effects
  • Colonic Neoplasms / physiopathology
  • Colonic Neoplasms / surgery*
  • Digestive System Surgical Procedures
  • Double-Blind Method
  • Female
  • Glutamine / administration & dosage
  • Glutamine / therapeutic use*
  • Humans
  • Intestinal Mucosa / drug effects*
  • Intestinal Mucosa / physiology
  • Male
  • Middle Aged
  • Parenteral Nutrition, Total / methods*
  • Stomach Neoplasms / physiopathology
  • Stomach Neoplasms / surgery*
  • Treatment Outcome


  • Glutamine