Abstract
A new facile synthesis has been developed for nanomolar Hsp90 inhibitor, cycloproparadicicol (2). Our approach relied on cobalt-complexation promoted RCM, in combination with tandem Diels-Alder/retro-Diels-Alder reactions to assemble the resorcycinylic macrolactone.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cyclization
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Cyclopropanes / cerebrospinal fluid*
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Lactones / cerebrospinal fluid*
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Macrolides / chemical synthesis*
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Resorcinols / chemical synthesis*
Substances
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Cyclopropanes
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Lactones
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Macrolides
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Resorcinols
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cycloproparadicicol