Abstract
The genomes of the tuberculin production strains Mycobacterium bovis AN5 and Mycobacterium tuberculosis DT were compared to genome-sequenced tubercle bacilli by using DNA microarrays. Neither the AN5 nor DT strain suffered extensive gene deletions during in vitro passage. This suggests that bovine tuberculin made from M. bovis AN5 is suitable to detect infection with presently prevalent M. bovis strains.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Gene Deletion
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Genome, Bacterial*
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Minisatellite Repeats
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Mycobacterium bovis / genetics
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Mycobacterium bovis / metabolism
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Mycobacterium tuberculosis / classification
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Mycobacterium tuberculosis / genetics*
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Mycobacterium tuberculosis / metabolism
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Oligonucleotide Array Sequence Analysis
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Species Specificity
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Tuberculin / genetics*