Cytokinesis: a logical GAP

Curr Biol. 2003 Aug 5;13(15):R589-91. doi: 10.1016/s0960-9822(03)00521-9.

Abstract

Two complexes localize to the central spindle and regulate completion of cytokinesis: one, centralspindlin, contains a kinesin-like protein and a Rho-family GAP; the second contains Aurora B kinase. Aurora B kinase is known to regulate localization of centralspindlin and may regulate the activity of the RhoGAP component of centralspindlin.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Aurora Kinases
  • Cell Division / physiology*
  • GTPase-Activating Proteins / metabolism*
  • Microtubule-Associated Proteins / metabolism*
  • Microtubules / metabolism
  • Microtubules / physiology*
  • Molecular Sequence Data
  • Protein-Serine-Threonine Kinases / metabolism*
  • Spindle Apparatus / physiology

Substances

  • GTPase-Activating Proteins
  • Microtubule-Associated Proteins
  • Aurora Kinases
  • Protein-Serine-Threonine Kinases