Expression of betaA2-crystallin in human lenses

Exp Eye Res. 2003 Sep;77(3):383-5. doi: 10.1016/s0014-4835(03)00156-8.


Evidence of betaA2-crystallin expression has been detected in human lenses. The protein, which co-elutes with betaA1/A3 from reversed phase HPLC separation of beta(L)-crystallins, accounts for 1-2% of the lens crystallins. Its molecular mass, M(r) 22 006, is consistent with the cDNA deduced sequence with addition of acetylation at the N-terminal serine residue. Approximately 20% of the protein is phosphorylated at Ser30.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetylation
  • Amino Acid Sequence
  • Humans
  • Lens, Crystalline / metabolism*
  • Mass Spectrometry / methods
  • Phosphorylation
  • beta-Crystallin A Chain / analysis*


  • beta-Crystallin A Chain