Antigen presenting cells and the immunogenetics of autoimmune diabetes in NOD mice

Reg Immunol. Sep-Oct 1992;4(5):263-73.


Genetically-controlled defects in the development and function of antigen presenting cells may explain why NOD mice exhibit an impaired ability to induce tolerance and/or activate immunoregulatory T cells. These defects provide understanding for why diabetogenesis in NOD mice is so sensitive to immunomodulatory changes mediated through the environment. Although the unique MHC haplotype of NOD mice is clearly a major contributor to diabetes susceptibility, evidence for a complex interaction between MHC loci and many other polygenetic factors is reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology
  • Autoimmune Diseases / genetics
  • Autoimmune Diseases / immunology*
  • Diabetes Mellitus, Type 1 / genetics
  • Diabetes Mellitus, Type 1 / immunology*
  • Haplotypes
  • Humans
  • Immunogenetics
  • Macrophages / immunology
  • Major Histocompatibility Complex
  • Mice
  • Mice, Inbred NOD