Coemergence of insomnia and a shift in the Th1/Th2 balance toward Th2 dominance

Neuroimmunomodulation. 2002-2003;10(6):337-43. doi: 10.1159/000071474.

Abstract

Objectives: Insomnia is associated with physical and mental disorders. We examined the effect of insomnia on immune functions, focusing on the T helper 1 (Th1)/ T helper 2 (Th2) balance, by a cross-sectional design.

Methods: We provided a self-administered questionnaire to evaluate sleep habits, smoking and medical disorders to 578 men without any toxic exposure (20-64 years old), and measured natural killer (NK) cell activity in 324 men and production of interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) after stimulation with phytohemagglutinin in 254 men. According to the criteria of DSM-IV, in which insomnia is classified into primary and secondary insomnia, we assessed the effect of insomnia on immune functions, controlling for age and smoking in groups with and without medical disorders.

Results: The prevalence of insomnia in the present study was 9.2%. In the absence of medical disorders, insomniac men had a significantly lower IFN-gamma and ratio of IFN-gamma to IL-4 than noninsomniac men. Men with insufficient sleep or difficulty initiating sleep (DIS) had a significantly lower IFN-gamma to IL-4 ratio than those not suffering from insufficient sleep or DIS. In the presence of medical disorders, insomniac men had significantly higher IL-4 than noninsomniac men. Men with difficulty maintaining sleep (DMS) had a significantly lower IFN-gamma to IL-4 ratio than men without DMS. NK cell activity was independent of insomnia.

Conclusions: The present results showed a link between insomnia unrelated to medical disorders and a shift in the Th1/Th2 balance toward Th2 dominance, indicating that the relationship between sleep quality and the etiology of immune-related diseases should be reconsidered.

MeSH terms

  • Adult
  • Cross-Sectional Studies
  • Down-Regulation / immunology
  • Humans
  • Interferon-gamma / drug effects
  • Interferon-gamma / immunology
  • Interleukin-4 / immunology
  • Killer Cells, Natural / drug effects
  • Killer Cells, Natural / immunology*
  • Lymphocyte Subsets / drug effects
  • Lymphocyte Subsets / immunology*
  • Male
  • Middle Aged
  • Neuroimmunomodulation / drug effects
  • Neuroimmunomodulation / immunology*
  • Phytohemagglutinins / pharmacology
  • Sleep Initiation and Maintenance Disorders / immunology*
  • Sleep Initiation and Maintenance Disorders / physiopathology
  • Smoking / immunology
  • Surveys and Questionnaires
  • Th1 Cells / drug effects
  • Th1 Cells / immunology*
  • Th2 Cells / drug effects
  • Th2 Cells / immunology*

Substances

  • Phytohemagglutinins
  • Interleukin-4
  • Interferon-gamma