Intracranial giant cell arteritis with fatal middle cerebral artery territory infarct

Clin Neuropathol. Jul-Aug 2003;22(4):199-203.

Abstract

A 37 year-old man who developed a fatal middle cerebral territory infarct was found at autopsy, to have widespread granulomatous angiitis involving meningeal and intracranial--extracerebral vessels but not intracerebral vessels or other extra-cranial vessels. The findings are unique and overlap with those of granulomatous angiitis of the nervous system (GANS) and classic giant cell arteritis (GCA). A possible precipitant for this devastating illness was a recent Chlamydia infection. The salient clinical and pathologic differences between GANS and GCA of the nervous system are discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Fatal Outcome
  • Giant Cell Arteritis / complications*
  • Giant Cell Arteritis / diagnosis
  • Giant Cell Arteritis / pathology
  • Humans
  • Infarction, Middle Cerebral Artery / diagnosis
  • Infarction, Middle Cerebral Artery / etiology*
  • Infarction, Middle Cerebral Artery / pathology*
  • Intracranial Arterial Diseases / complications*
  • Intracranial Arterial Diseases / diagnosis
  • Intracranial Arterial Diseases / pathology*
  • Lymphocytosis / cerebrospinal fluid
  • Male