DExD/H-box proteins and their partners: helping RNA helicases unwind

Gene. 2003 Jul 17;312:1-16. doi: 10.1016/s0378-1119(03)00626-7.


Members of the DExD/H-box family of RNA helicases are involved in many processes and complexes within the cell. While individual DExD/H helicase family members have been studied extensively, the mechanisms through which helicases affect multiprotein complexes are just beginning to be investigated. Because RNA helicases are both highly conserved and numerous in the cell, study of RNA helicase recruitment and modulation by cofactors is necessary for understanding the mechanisms of helicase action in vivo. This review will focus on cofactor-mediated regulation of helicase target specificity and activity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Motifs / genetics
  • Amino Acid Sequence
  • Animals
  • Humans
  • Molecular Sequence Data
  • Nucleic Acid Conformation
  • RNA / chemistry
  • RNA / genetics
  • RNA / metabolism*
  • RNA Helicases / genetics*
  • RNA Helicases / metabolism
  • RNA Splicing
  • Sequence Homology, Amino Acid


  • RNA
  • RNA Helicases