Effects of Petroselinum crispum extract on pancreatic B cells and blood glucose of streptozotocin-induced diabetic rats

Biol Pharm Bull. 2003 Aug;26(8):1206-10. doi: 10.1248/bpb.26.1206.


This study investigated both morphologically and biochemically whether parsley (Petroselinum crispum), which is used as a folk remedy to decrease blood glucose, has any antidiabetic effect on pancreatic B cells of rats. Parsley extract was given to male diabetic rats. In the diabetic group given parsley extract, it was detected that the number of secretory granules and cells in islets and other morphologic changes were not different from the control diabetic group, while the blood glucose levels in the diabetic group given the plant extract were reduced in comparison to the diabetic group. In addition, a decrease was observed in the weight of the control diabetic group and the diabetic group given the plant extract. It is suggested that the plant therapy can provide blood glucose homeostasis and cannot regenerate B cells of the endocrine pancreas.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Glucose / drug effects*
  • Blood Glucose / metabolism
  • Diabetes Mellitus, Experimental / blood
  • Diabetes Mellitus, Experimental / drug therapy*
  • Diabetes Mellitus, Experimental / pathology
  • Islets of Langerhans / drug effects*
  • Islets of Langerhans / metabolism
  • Male
  • Petroselinum* / chemistry
  • Petroselinum* / physiology
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*
  • Rats


  • Blood Glucose
  • Plant Extracts