Reversion of 'early worsening' of diabetic retinopathy by deliberate restoration of poor metabolic control

Ophthalmologica. Sep-Oct 2003;217(5):373-7. doi: 10.1159/000071355.


Acutely lowering long-standing severe hyperglycaemia can trigger progression ('early worsening') of diabetic retinopathy, most likely by up-regulation of the circulating insulin-like growth factor 1 (IGF-1). This condition, also called 'florid retinopathy', rarely responds to standard laser coagulation treatment. In this retrospective report, 2 young patients with type 2 diabetes are described, in whom deliberate restoration of poor diabetes control reduced the serum IGF-1 levels and improved 'early worsened' diabetic retinopathy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Blood Glucose / analysis
  • Diabetes Mellitus, Type 2 / physiopathology
  • Diabetic Retinopathy / physiopathology*
  • Female
  • Fluorescein Angiography
  • Glycated Hemoglobin A / metabolism
  • Humans
  • Hyperglycemia / drug therapy*
  • Hyperglycemia / physiopathology*
  • Insulin / therapeutic use
  • Insulin-Like Growth Factor I / metabolism
  • Retrospective Studies
  • Up-Regulation
  • Visual Acuity


  • Blood Glucose
  • Glycated Hemoglobin A
  • Insulin
  • Insulin-Like Growth Factor I