Nuclear receptors: a rendezvous for chromatin remodeling factors

Cell. 2003 Aug 8;114(3):277-80. doi: 10.1016/s0092-8674(03)00599-3.

Abstract

Nuclear receptors (NRs) are a large family of ligand-induced transcription factors that include the vitamin D receptor. The recent discovery of WINAC, a novel ATP-dependent chromatin remodeling complex, has shed new light on the molecular mechanisms by which the vitamin D receptor controls gene expression with unexpected clinical implications.

Publication types

  • Review

MeSH terms

  • Chromatin / metabolism*
  • Humans
  • Models, Genetic
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Transcription Factors
  • Vitamin D / genetics
  • Vitamin D / metabolism
  • Williams Syndrome / genetics

Substances

  • Chromatin
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • Vitamin D