Efficacy of albendazole and short-course dexamethasone treatment in children with 1 or 2 ring-enhancing lesions of neurocysticercosis: a randomized controlled trial

J Pediatr. 2003 Jul;143(1):111-4. doi: 10.1016/S0022-3476(03)00211-7.

Abstract

Objective: To determine the efficacy of albendazole plus dexamethasone in children with 1 or 2 ring-enhancing lesions (by computed tomography scan) on resolution of lesions and recurrence of seizure.

Study design: Randomized controlled open trial.

Methods: Children of either sex, 1 to 14 years of age, with seizures and 1 or 2 ring-enhancing lesions <20 mm in diameter on computed tomography scan, likely to have neurocysticercosis, were assigned to treatment l groups. Children assigned to the treatment group (n=61) were given 0.15 mg/kg per day dexamethasone for 5 days plus 15 mg/kg per day albendazole for 28 days, starting on the third day of dexamethasone. Control group (n=62) children were given neither dexamethasone or albendazole. Anti-epileptic therapy was given to both the study groups.

Results: The lesions resolved completely or partially in more children in the treated group compared with the control group (79% versus 57%; P=.02). The proportion of children who had seizures was significantly lower in the treated group compared with the control group at 3 months (10% versus 32%; P=.006) and 6 months (13% versus 33%; P=.03).

Conclusions: Albendazole plus dexamethasone increased complete or partial resolution of lesions and reduced the risk of subsequent recurrence of seizures among children with neurocysticercosis who had with seizures and 1 or 2 ring-enhancing lesions on computed tomography.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Albendazole / administration & dosage
  • Albendazole / therapeutic use*
  • Anthelmintics / administration & dosage
  • Anthelmintics / therapeutic use*
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / therapeutic use*
  • Anticonvulsants / therapeutic use
  • Brain / diagnostic imaging*
  • Brain / parasitology
  • Brain Edema / diagnostic imaging*
  • Brain Edema / parasitology
  • Child
  • Child, Preschool
  • Dexamethasone / administration & dosage
  • Dexamethasone / therapeutic use*
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Male
  • Neurocysticercosis / diagnostic imaging*
  • Neurocysticercosis / drug therapy*
  • Neurocysticercosis / parasitology
  • Phenytoin / therapeutic use
  • Recurrence
  • Seizures / diagnosis
  • Seizures / drug therapy
  • Seizures / etiology
  • Tomography, X-Ray Computed

Substances

  • Anthelmintics
  • Anti-Inflammatory Agents
  • Anticonvulsants
  • Phenytoin
  • Dexamethasone
  • Albendazole