A novel traceless solid-phase Friedländer synthesis

Org Lett. 2003 Aug 21;5(17):3061-3. doi: 10.1021/ol035049z.

Abstract

[reaction: see text] A new solid-phase synthesis of quinolines based on a Friedländer-type reaction between the resin-bound azomethine 1b and ketones 2 is described. This cyclative cleavage approach affords quinolines 3a-f in 50-81% yields. The polymer-bound aniline equivalent is easily recycled and may be reused with comparable performance.