Expression of class I MHC molecule, HSP70 and TAP in human hepatocellular carcinoma

World J Gastroenterol. 2003 Aug;9(8):1853-5. doi: 10.3748/wjg.v9.i8.1853.


Aim: To demonstrate whether class I MHC molecule, transporter associated with antigen processing (TAP), and heat-shock proteion70 (HSP70) expressed in liver cancer cells before the design and construction of CTL vaccine against hepatocellular carcinoma (HCC).

Methods: We studied 30 HCC specimens by labeled streptavidin biotin (LSAB) method of immunohistochemistry.

Results: The results showed that the majority of HCC cells investigated naturally expressed class I MHC and TAP, which were different from other tumor cells. Furthermore, we found that HSP70 expressed not only in cellular cytoplasm, but also on the cell surface in HCC.

Conclusion: Our findings indicate that our understanding about immune escape mechanisms employed by HCC cells may be further improved. It is important to design and construct CTL vaccine against HCC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP-Binding Cassette Transporters
  • Carcinoma, Hepatocellular / metabolism*
  • HSP70 Heat-Shock Proteins / metabolism*
  • Histocompatibility Antigens Class I / metabolism*
  • Humans
  • Immunohistochemistry
  • Liver Neoplasms / metabolism*


  • ATP-Binding Cassette Transporters
  • HSP70 Heat-Shock Proteins
  • Histocompatibility Antigens Class I
  • transporter associated with antigen processing (TAP)