Objective: To evaluate the effects of early and delayed overdriving pacing preconditioning on the concentration of nitric oxide (NO), superoxide dismutase (SOD) and malondialdehyde (MDA) in blood.
Methods: Forty-eight rabbits were divided into control (C) group, ischemia-reperfusion (IR) group, overdriving pacing preconditioning (PP) group and delayed protection (DP) group. The concentrations of NO, SOD, MDA in the coronary sinus were detected during the ischemia-reperfusion.
Results: The levels of NO in the coronary sinus of PP and DP group were higher than that of IR group, the levels of MDA of PP and DP group were lower than that of IR group.
Conclusion: PP and DP could alleviate the injury by the oxygen free radicals during the myocardial ischemia-reperfusion.