Marine bacteria associated with sponge as source of cyclic peptides

Biomol Eng. 2003 Jul;20(4-6):311-6. doi: 10.1016/s1389-0344(03)00038-8.


Two bacteria associated with the marine sponge Ircinia variabilis were isolated using commercial and experimental media. The use of media containing marine derived proteins improved the growth of both isolated bacteria, showing that marine bacteria need of marine derived proteins for a better growth. The composition of free and total fatty acids of both strains cultivated under different carbon source was investigated. Several diketopiperazines were isolated from both bacteria and the hypothesis of their role in the bacterial-spongy interaction is discussed.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bacillus / classification
  • Bacillus / growth & development*
  • Bacillus / isolation & purification
  • Bacillus / metabolism*
  • Fatty Acids / metabolism*
  • Peptides, Cyclic / classification
  • Peptides, Cyclic / metabolism*
  • Porifera / microbiology*
  • Species Specificity
  • Staphylococcus / classification
  • Staphylococcus / growth & development*
  • Staphylococcus / isolation & purification
  • Staphylococcus / metabolism*
  • Symbiosis / physiology*


  • Fatty Acids
  • Peptides, Cyclic