Abstract
Normal human epidermal melanocytes became swollen and more dendritic with an increase in the amount of tyrosinase and immunoreactive b-locus protein when they were cultured for 2 days with the following arachidonic acid metabolites: prostaglandin (PG) D2, leukotriene (LT) B4, LTC4, LTD4, LTE4, thromboxane (TX) B2 and 12-hydroxy eicosatetraenoic acid (12-HETE). The effect of LTC4 was particularly strong compared to that of PGE2, about which we have previously reported. On the other hand, PGE1, PGF2 alpha and 6-ketoPGF1 alpha did not show any significant stimulatory effect. These data suggest that arachidonate-derived chemical mediators, especially LTC4, may be responsible for the induction of post-inflammatory hyperpigmentation of the skin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
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Adult
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Arachidonic Acids / metabolism*
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Cell Division / physiology
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Fibroblast Growth Factor 2 / pharmacology
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Fluorescent Antibody Technique
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Humans
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Hydroxyeicosatetraenoic Acids / pharmacology
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Inflammation / physiopathology
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Leukotrienes / pharmacology
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Male
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Melanocytes / cytology
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Melanocytes / enzymology
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Melanocytes / physiology*
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Monophenol Monooxygenase / metabolism
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Monophenol Monooxygenase / physiology
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Prostaglandin D2 / pharmacology
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Skin Pigmentation / drug effects
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Skin Pigmentation / physiology*
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Thromboxane B2 / pharmacology
Substances
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Arachidonic Acids
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Hydroxyeicosatetraenoic Acids
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Leukotrienes
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Fibroblast Growth Factor 2
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Thromboxane B2
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12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
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Monophenol Monooxygenase
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Prostaglandin D2