Linezolid clearance during continuous venovenous hemodiafiltration: a case report

Pharmacotherapy. 2003 Aug;23(8):1071-5. doi: 10.1592/phco.23.8.1071.32874.

Abstract

Objective: To determine the linezolid clearance and serum concentrations in a critically ill man receiving continuous venovenous hemodiafiltration (CVVHDF).

Methods: Intravenous linezolid 600 mg every 12 hours was administered to a critically ill, 85-year-old man with anuria who was receiving CVVHDF at a dialysate flow rate of 2000 ml/hour and a mean ultrafiltrate production rate of 775 ml/hour. Samples of blood and spent dialysate and ultrafiltrate were obtained at the time of linezolid peaks and troughs, and linezolid concentrations were determined.

Results: The CVVHDF yielded a mean linezolid clearance of 36.5 ml/minute and an elimination half-life of 7.5 hours. The linezolid saturation coefficient ranged from 0.77-0.81. Administration of intravenous linezolid 600 mg every 12 hours yielded suitable serum trough concentrations.

Conclusion: Administration of intravenous linezolid 600 mg every 12 hours maintained therapeutic serum trough concentrations in this critically ill patient receiving CVVHDF.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / administration & dosage
  • Acetamides / blood
  • Acetamides / pharmacokinetics*
  • Aged
  • Aged, 80 and over
  • Anti-Infective Agents / administration & dosage
  • Anti-Infective Agents / blood
  • Anti-Infective Agents / pharmacokinetics*
  • Anuria / therapy*
  • Area Under Curve
  • Chromatography, High Pressure Liquid
  • Critical Illness / therapy
  • Drug Administration Schedule
  • Half-Life
  • Hemofiltration
  • Humans
  • Linezolid
  • Male
  • Oxazolidinones / administration & dosage
  • Oxazolidinones / blood
  • Oxazolidinones / pharmacokinetics*

Substances

  • Acetamides
  • Anti-Infective Agents
  • Oxazolidinones
  • Linezolid