Constitutive phosphorylation of FKHR transcription factor as a prognostic variable in acute myeloid leukemia

Leuk Res. 2003 Dec;27(12):1159-62. doi: 10.1016/s0145-2126(03)00102-4.

Abstract

The transcription factor FKHR, which is controlled by Akt-PKB signaling, is involved in regulating cell cycle progression and cell death. In this study, the phosphorylation of FKHR was observed in 45 (73.8%) of 61 patients with acute myeloid leukemia (AML). The phosphorylation of Akt-PKB was found to be significantly associated with phospho-FKHR (P<0.001). Patients with phospho-FKHR had a significantly shorter overall survival than those without (P<0.05). In conclusion, the constitutive phosphorylation of FKHR was observed in the majority of AML, and the detection of phospho-FKHR might provide a new tool for identifying AML patients with an unfavorable outcome.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Blotting, Western
  • DNA-Binding Proteins / metabolism*
  • Female
  • Forkhead Box Protein O1
  • Forkhead Transcription Factors
  • Gene Expression Regulation, Leukemic*
  • Gene Expression Regulation, Neoplastic*
  • Genes, Tumor Suppressor
  • Glycogen Synthase Kinase 3 / metabolism
  • Glycogen Synthase Kinase 3 beta
  • Humans
  • Leukemia, Myeloid / metabolism*
  • Leukemia, Myeloid / pathology
  • Male
  • Middle Aged
  • PTEN Phosphohydrolase
  • Phosphoric Monoester Hydrolases / metabolism
  • Phosphorylation
  • Prognosis
  • Protein-Serine-Threonine Kinases*
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-akt
  • Survival Rate
  • Transcription Factors / metabolism*
  • Tumor Suppressor Proteins / metabolism

Substances

  • DNA-Binding Proteins
  • FOXO1 protein, human
  • Forkhead Box Protein O1
  • Forkhead Transcription Factors
  • Proto-Oncogene Proteins
  • Transcription Factors
  • Tumor Suppressor Proteins
  • AKT1 protein, human
  • Glycogen Synthase Kinase 3 beta
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt
  • Glycogen Synthase Kinase 3
  • Phosphoric Monoester Hydrolases
  • PTEN Phosphohydrolase
  • PTEN protein, human