RGD modified polymers: biomaterials for stimulated cell adhesion and beyond

Biomaterials. 2003 Nov;24(24):4385-415. doi: 10.1016/s0142-9612(03)00343-0.


Since RGD peptides (R: arginine; G: glycine; D: aspartic acid) have been found to promote cell adhesion in 1984 (Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule, Nature 309 (1984) 30), numerous materials have been RGD functionalized for academic studies or medical applications. This review gives an overview of RGD modified polymers, that have been used for cell adhesion, and provides information about technical aspects of RGD immobilization on polymers. The impacts of RGD peptide surface density, spatial arrangement as well as integrin affinity and selectivity on cell responses like adhesion and migration are discussed.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biocompatible Materials / chemical synthesis
  • Biocompatible Materials / chemistry*
  • Biocompatible Materials / pharmacology
  • Cell Adhesion / drug effects
  • Cell Adhesion / physiology*
  • Cell Line
  • Cell Line, Tumor
  • Humans
  • Integrins
  • Models, Biological
  • Models, Molecular
  • Oligopeptides / pharmacology*
  • Peptide Fragments / chemical synthesis
  • Peptide Fragments / chemistry
  • Peptide Fragments / pharmacology
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / pharmacology


  • Biocompatible Materials
  • Integrins
  • Oligopeptides
  • Peptide Fragments
  • Peptides, Cyclic
  • arginyl-glycyl-aspartic acid