Concentration of caveolin-3 at the neuromuscular junction in young and old rat skeletal muscle fibers

J Histochem Cytochem. 2003 Sep;51(9):1113-8. doi: 10.1177/002215540305100901.

Abstract

Caveolin-3, a muscle-specific member of the caveolin family, is strongly localized to the neuromuscular junction (NMJ) in adult rat muscle fibers, where it co-localizes with alpha-bungarotoxin staining. In 24-month-old rats, less distinct staining corresponds with the normal aging changes in the NMJ. After denervation, the pattern and intensity of staining begin to break up as early as 3 days, and by 10 days little staining remains. The functional implications of this concentration of caveolin-3 at the NMJ remain obscure, but it is possible that its absence could account for some of the phenotypic characteristics of individuals with caveolin-3 mutations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Animals
  • Caveolin 3
  • Caveolins / metabolism*
  • Immunohistochemistry
  • Male
  • Microscopy, Fluorescence
  • Muscle Fibers, Skeletal / metabolism*
  • Muscle, Skeletal / metabolism*
  • Muscle, Skeletal / ultrastructure
  • Neuromuscular Junction / metabolism*
  • Rats
  • Rats, Sprague-Dawley
  • Rats, Wistar

Substances

  • Cav3 protein, rat
  • Caveolin 3
  • Caveolins