The SREBP pathway--insights from Insigs and insects

Nat Rev Mol Cell Biol. 2003 Aug;4(8):631-40. doi: 10.1038/nrm1174.


Animal cells coordinate lipid homeostasis by end-product feedback regulation of transcription. The control occurs through the proteolytic release of transcriptionally active sterol regulatory element binding proteins (SREBPs) from intracellular membranes. This feedback system has unexpected features that are found in all cells. Here, we consider recently discovered components of the regulatory machinery that govern SREBP processing, as well as studies in Drosophila that indicate an ancient role for the SREBP pathway in integrating membrane composition and lipid biosynthesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • CCAAT-Enhancer-Binding Proteins / metabolism*
  • Cell Membrane / metabolism
  • DNA-Binding Proteins / metabolism*
  • Humans
  • Insect Proteins / metabolism*
  • Intracellular Signaling Peptides and Proteins
  • Lipid Metabolism*
  • Lipids / chemistry
  • Membrane Proteins / metabolism
  • Metalloendopeptidases / metabolism
  • Molecular Structure
  • Sterol Regulatory Element Binding Protein 1
  • Sterols / chemistry
  • Sterols / metabolism
  • Transcription Factors*


  • CCAAT-Enhancer-Binding Proteins
  • DNA-Binding Proteins
  • Insect Proteins
  • Intracellular Signaling Peptides and Proteins
  • Lipids
  • Membrane Proteins
  • SREBF1 protein, human
  • SREBP cleavage-activating protein
  • Sterol Regulatory Element Binding Protein 1
  • Sterols
  • Transcription Factors
  • Metalloendopeptidases
  • MBTPS2 protein, human