Transactivation joins multiple tracks to the ERK/MAPK cascade

Nat Rev Mol Cell Biol. 2003 Aug;4(8):651-7. doi: 10.1038/nrm1173.


Many agonists of G-protein-coupled receptors (GPCRs) can stimulate receptor tyrosine kinases and the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway. A 'transactivation' mechanism, which links these events in one signalling chain, inspired many researchers, but inevitably raised new questions. A 'multi-track' model for GPCR signalling to the ERK/MAPK pathway might resolve some of the puzzles in the transactivation field.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Enzyme Activation
  • ErbB Receptors / metabolism
  • GTP-Binding Proteins / metabolism*
  • Humans
  • MAP Kinase Signaling System / physiology*
  • Metalloendopeptidases / metabolism
  • Mitogen-Activated Protein Kinases / metabolism*
  • Models, Biological


  • ErbB Receptors
  • Mitogen-Activated Protein Kinases
  • Metalloendopeptidases
  • GTP-Binding Proteins