Chromosome aberrations in solid tumors

Nat Genet. 2003 Aug;34(4):369-76. doi: 10.1038/ng1215.


Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Biological Evolution
  • Chromosome Aberrations*
  • Gene Dosage
  • Humans
  • Models, Genetic
  • Neoplasms / diagnosis
  • Neoplasms / etiology
  • Neoplasms / genetics*
  • Neoplasms / physiopathology
  • Oncogenes
  • Prognosis
  • Receptor Protein-Tyrosine Kinases / genetics
  • Signal Transduction / genetics


  • Receptor Protein-Tyrosine Kinases