Protective activity of tomato products on in vivo markers of lipid oxidation

Eur J Nutr. 2003 Aug;42(4):201-6. doi: 10.1007/s00394-003-0415-5.


Background: It has been suggested that regular consumption of tomato products improves antioxidant defenses due to their endogenous antioxidant compounds, notably lycopene.

Aim of the study: We evaluated the effects of tomato consumption on parameters of lipid oxidation in healthy human volunteers.

Methods: Twelve females (enrolled at T-7), after a one-week of carotenoid-poor diet (T0), were instructed to supplement the same diet with different tomato products (raw, sauce, and paste), thereby providing approximately eight mg lycopene/day for three weeks (T21). Blood samples were periodically collected in order to evaluate plasma carotenoid concentrations, plasma antioxidant capacity, and susceptibility of LDL to metal ion-induced oxidation. Furthermore, 8-iso-PGF(2alpha), a marker of in vivo oxidative stress, was analyzed in the 24-hour urine.

Results: Carotenoid concentrations decreased significantly during the carotenoid-poor diet (P < 0.05), while lycopene concentrations increased significantly after tomato consumption (P < 0.001). The antioxidant capacity of plasma did not vary during the study. Conversely, LDL oxidizability decreased after tomato consumption, as demonstrated by a shortening of the lag phase (P < 0.001). This parameter was significantly correlated with lycopene concentration (r = 0.36, P < 0.05). The excretion of 8-iso-PGF(2alpha) in urine was also significantly lower (-53%, P < 0.05 compared with T0) after tomato supplementation.

Conclusions: These results further support a role for tomato products in the prevention of lipid peroxidation, a risk factor of atherosclerosis and cardiovascular disease.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Antioxidants / pharmacology*
  • Biomarkers / urine
  • Carotenoids / blood
  • Carotenoids / pharmacology*
  • Cholesterol, LDL / metabolism
  • Cross-Over Studies
  • Dinoprost* / analogs & derivatives*
  • F2-Isoprostanes / urine
  • Female
  • Humans
  • Lipid Peroxidation / drug effects*
  • Lycopene
  • Oxidation-Reduction
  • Oxidative Stress / physiology*
  • Solanum lycopersicum / chemistry*


  • Antioxidants
  • Biomarkers
  • Cholesterol, LDL
  • F2-Isoprostanes
  • 8-epi-prostaglandin F2alpha
  • Carotenoids
  • Dinoprost
  • Lycopene