In vivo evaluation of an electroenzymatic glucose sensor implanted in subcutaneous tissue

Biosens Bioelectron. 1992;7(10):709-14. doi: 10.1016/0956-5663(92)85053-d.


Cleanroom processing techniques have been used to mass-produce flexible, electroenzymatic glucose sensors designed for implantation in subcutaneous tissue. In vitro characterization studies have shown the sensor's performance to be acceptable. Initial in vivo studies were conducted with the sensor implanted in the subcutaneous tissue of rabbits. Sensors implanted in the subcutaneous tissue of normal human subjects showed an excellent correlation between glucose concentrations measured by the sensor and capillary finger sticks measured with a commercial analyzer.

MeSH terms

  • Animals
  • Biosensing Techniques*
  • Blood Glucose / metabolism*
  • Connective Tissue / blood supply*
  • Disposable Equipment*
  • Electrodes, Implanted
  • Humans
  • Monitoring, Physiologic / methods
  • Rabbits
  • Reproducibility of Results


  • Blood Glucose