New TRP channels in hearing and mechanosensation

Neuron. 2003 Aug 14;39(4):585-8. doi: 10.1016/s0896-6273(03)00505-1.


Despite extensive biophysical characterization and the superb example of the bacterial MscL channel, molecular identification of eukaryotic mechanosensitive channels has been slow. New members of the TRP superfamily have emerged as candidate channels to mediate touch, hearing, fluid flow, and osmosensation in sensory and nonsensory cells. Distinguishing between direct mechanical activation and indirect second messenger activation is still a challenge.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Calcium Channels / physiology*
  • Hearing / physiology*
  • Humans
  • Mechanoreceptors / physiology*
  • Mechanotransduction, Cellular / physiology*
  • TRPC Cation Channels


  • Calcium Channels
  • TRPC Cation Channels