The hereditary spastic paraplegias: nine genes and counting

John K Fink

doi:10.1001/archneur.60.8.1045

The hereditary spastic paraplegias: nine genes and counting

Arch Neurol. 2003 Aug;60(8):1045-9. doi: 10.1001/archneur.60.8.1045.

Author

John K Fink¹

Affiliation

¹ Department of Neurology, University of Michigan, 5214 Cancer Geriatrics Center Bldg., Box 0940, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. jkfink@umich.edu

PMID: 12925358
DOI: 10.1001/archneur.60.8.1045

Abstract

The hereditary spastic paraplegias (HSPs) are inherited neurologic disorders in which the primary symptom is insidiously progressive difficulty walking due to lower extremity weakness and spasticity. There have been great strides in our knowledge of this group of disabling disorders; 20 HSP loci and 9 HSP genes have been discovered. Insights into the molecular causes of HSPs are beginning to emerge. This review summarizes these advances in HSPs' genetics.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Genotype
Humans
Mutation
Phenotype
Spastic Paraplegia, Hereditary / classification*
Spastic Paraplegia, Hereditary / genetics*

Abstract

Publication types

MeSH terms

Grants and funding