The hereditary spastic paraplegias: nine genes and counting

Arch Neurol. 2003 Aug;60(8):1045-9. doi: 10.1001/archneur.60.8.1045.


The hereditary spastic paraplegias (HSPs) are inherited neurologic disorders in which the primary symptom is insidiously progressive difficulty walking due to lower extremity weakness and spasticity. There have been great strides in our knowledge of this group of disabling disorders; 20 HSP loci and 9 HSP genes have been discovered. Insights into the molecular causes of HSPs are beginning to emerge. This review summarizes these advances in HSPs' genetics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Genotype
  • Humans
  • Mutation
  • Phenotype
  • Spastic Paraplegia, Hereditary / classification*
  • Spastic Paraplegia, Hereditary / genetics*