Synthesis and hydrolysis studies of a peptide containing the reactive triad of serine proteases with an associated linker to a dye on a solid phase support

John M Clough; Ray V Jones; Hannah McCann; David J Morris; Martin Wills

doi:10.1039/b302239k

Synthesis and hydrolysis studies of a peptide containing the reactive triad of serine proteases with an associated linker to a dye on a solid phase support

Org Biomol Chem. 2003 May 7;1(9):1486-97. doi: 10.1039/b302239k.

Authors

John M Clough¹, Ray V Jones, Hannah McCann, David J Morris, Martin Wills

Affiliation

¹ Syngenta, Jealott's Hill Research Centre, Bracknell, Berkshire, UK RG42 6EY.

PMID: 12926277
DOI: 10.1039/b302239k

Abstract

The synthesis of a Tentagel-supported peptide incorporating the reactive triad of serine, histidine and aspartic acid, found within serine protease enzymes, is described.

MeSH terms

Amino Acid Sequence
Aspartic Acid / chemistry
Aspartic Acid / metabolism
Coloring Agents / chemistry
Combinatorial Chemistry Techniques / methods*
Esterases / chemistry
Histidine / chemistry
Histidine / metabolism
Hydrolysis
Microspheres
Molecular Sequence Data
Oligopeptides / chemical synthesis*
Oligopeptides / chemistry
Serine / chemistry
Serine / metabolism
Serine Endopeptidases / chemistry*
Serine Endopeptidases / metabolism

Substances

Coloring Agents
Oligopeptides
Aspartic Acid
Serine
Histidine
Esterases
Serine Endopeptidases