Interleukin 8 (IL-8) in the bronchoalveolar lavage fluid from patients with the adult respiratory distress syndrome (ARDS) and patients at risk for ARDS

Cytokine. 1992 Nov;4(6):592-7. doi: 10.1016/1043-4666(92)90025-m.


A sensitive and specific radioimmunoassay was used to measure interleukin 8 (IL-8) in bronchoalveolar lavage fluids from control subjects, patients with the adult respiratory distress syndrome (ARDS) and patients undergoing coronary bypass surgery, a risk factor for developing ARDS. Concentrations of IL-8, albumin, total protein and numbers of neutrophils were higher in both patient groups than in controls. Levels of IL-8 were significantly correlated with the influx of neutrophils, plasma protein extravasation and with the PaO2/FiO2 ratio. These data suggest that IL-8 may mediate the recruitment of neutrophils from the vascular compartment into the alveolar space and may therefore be an important determinant in neutrophil-mediated lung injury. Since increased levels of IL-8 were also found in BAL fluid from patients at risk in whom ARDS did not develop, other factors are likely to be involved and IL-8, as well as other markers of inflammation, are of little prognostic use.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Bronchoalveolar Lavage Fluid / immunology*
  • Coronary Artery Bypass / adverse effects
  • Female
  • Humans
  • Interleukin-8 / analysis
  • Interleukin-8 / metabolism*
  • Male
  • Middle Aged
  • Postoperative Complications / etiology
  • Postoperative Complications / immunology
  • Radioimmunoassay / methods
  • Radioimmunoassay / statistics & numerical data
  • Respiratory Distress Syndrome / etiology
  • Respiratory Distress Syndrome / immunology*
  • Risk Factors
  • Sensitivity and Specificity


  • Interleukin-8