Serum concentrations of acute-phase proteins in dogs with leishmaniosis during short-term treatment

Am J Vet Res. 2003 Aug;64(8):1021-6. doi: 10.2460/ajvr.2003.64.1021.


Objective: To evaluate changes in serum concentrations of acute-phase proteins in dogs with leishmaniosis during short-term therapy in accordance with 2 treatment protocols and determine whether concentrations of acute-phase proteins could be used to monitor the initial response of dogs to treatment.

Animals: 12 dogs naturally infected with Leishmania infantum.

Procedure: Dogs were allocated into 2 groups. Dogs of group 1 were treated by use of meglumine antimonate (100 mg/kg, SC, q 24 h) administered concurrently with allopurinol (15 mg/kg, PO, q 12 h) for 20 days and then with allopurinol alone at the same dosage for the subsequent 30 days. Dogs of group 2 were treated by administration of allopurinol alone (15 mg/kg, PO, q 12 h) for 60 days). Blood samples were obtained before and during treatment for measurement of serum concentrations of acute-phase proteins and determination of CBC counts, serum biochemical analyses, and electropherograms.

Results: All dogs evaluated in the study had increased concentrations of C-reactive protein, haptoglobin, and ceruloplasmin at the time of diagnosis of leishmaniosis. Mean concentration of serum amyloid A before treatment was also increased, but some of the dogs had concentrations of serum amyloid A that were within the reference range. Concentrations of C-reactive protein and ceruloplasmin decreased significantly in all dogs at the end of the study period.

Conclusions and clinical relevance: Measurement of concentrations of selected acute-phase proteins, such as C-reactive protein or ceruloplasmin, could be used to evaluate the initial response of dogs with leishmaniosis to treatment.

Publication types

  • Clinical Trial

MeSH terms

  • Acute-Phase Proteins / analysis*
  • Allopurinol / administration & dosage
  • Allopurinol / therapeutic use*
  • Animals
  • Antiprotozoal Agents / administration & dosage
  • Antiprotozoal Agents / therapeutic use
  • Dog Diseases / blood*
  • Dog Diseases / drug therapy*
  • Dogs
  • Drug Administration Schedule / veterinary
  • Drug Therapy, Combination
  • Female
  • Leishmaniasis, Visceral / blood*
  • Leishmaniasis, Visceral / drug therapy*
  • Leishmaniasis, Visceral / veterinary
  • Male
  • Meglumine / administration & dosage
  • Meglumine / therapeutic use*
  • Meglumine Antimoniate
  • Organometallic Compounds / administration & dosage
  • Organometallic Compounds / therapeutic use*


  • Acute-Phase Proteins
  • Antiprotozoal Agents
  • Organometallic Compounds
  • Allopurinol
  • Meglumine
  • Meglumine Antimoniate