The diagnosis and management of pre-invasive breast disease: ductal carcinoma in situ (DCIS) and atypical ductal hyperplasia (ADH)--current definitions and classification

Breast Cancer Res. 2003;5(5):254-7. doi: 10.1186/bcr623. Epub 2003 Jul 29.


Intraductal epithelial proliferations of the breast are at present classified into three groups; distinction is made histologically and clinically between usual epithelial hyperplasia and atypical ductal hyperplasia (ADH) and between ADH and ductal carcinoma in situ (DCIS). Although evidence indicates that these boundaries are not ideal on a morphological, immunohistochemical, or genetic basis, this three-tier system is accepted and used at present. The current definitions, histological features, and system of classification of ADH and DCIS are described in this manuscript.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms / classification
  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / pathology*
  • Breast Neoplasms / therapy
  • Carcinoma in Situ / diagnosis*
  • Carcinoma in Situ / pathology*
  • Carcinoma, Intraductal, Noninfiltrating / classification
  • Carcinoma, Intraductal, Noninfiltrating / diagnosis*
  • Carcinoma, Intraductal, Noninfiltrating / pathology*
  • Carcinoma, Intraductal, Noninfiltrating / therapy
  • Diagnosis, Differential
  • Female
  • Humans
  • Hyperplasia
  • Neoplasm Invasiveness
  • Precancerous Conditions / classification
  • Precancerous Conditions / diagnosis*
  • Precancerous Conditions / pathology*
  • Precancerous Conditions / therapy