Molecular diversity through sugar scaffolds

Drug Discov Today. 2003 Aug 1;8(15):701-9. doi: 10.1016/s1359-6446(03)02751-x.


Monosaccharides provide an excellent platform to tailor molecular diversity by appending desired substituents at selected positions around the sugar scaffold. The presence of five functionalized and stereo-controlled centres on the sugar scaffolds gives the chemist plenty of scope to custom design molecules to a pharmacophore model. This review focuses on the peptidomimetic developments in this area, as well as the concept of tailoring structural and functional diversity in a library using carbohydrate scaffolds and how this can lead to increased hit rates and rapid identification of leads, which has promising prospects for drug development.

Publication types

  • Review

MeSH terms

  • Animals
  • Carbohydrates / chemistry*
  • Combinatorial Chemistry Techniques / methods*
  • Humans
  • Molecular Conformation
  • Molecular Structure
  • Stereoisomerism


  • Carbohydrates