Abstract
Various studies suggested that inflammation is involved in the pathogenesis of Alzheimer's disease (AD). We investigated cytokine release from LPS-stimulated blood cells of 32 AD patients, with different disease severity, compared to 16 age-related controls. A significant decrease of IL-1beta and IL-6 secretion was observed in severely demented patients; TNF-alpha release was also decreased, but not significantly. By contrast, mild and moderate patients showed a cytokine release similar to controls. IL-1beta, IL-6 and TNF-alpha secretion was negatively correlated with the severity of dementia, quantified by the MMSE. Our data suggest that alterations of the immune profile are associated with AD progression.
Publication types
-
Clinical Trial
-
Controlled Clinical Trial
MeSH terms
-
Aged
-
Aged, 80 and over
-
Aging / blood
-
Aging / immunology
-
Alzheimer Disease / blood
-
Alzheimer Disease / classification
-
Alzheimer Disease / immunology*
-
Biomarkers / blood
-
Cortisone / blood
-
Female
-
Humans
-
In Vitro Techniques
-
Interleukin-1 / blood
-
Interleukin-1 / metabolism*
-
Interleukin-6 / blood
-
Interleukin-6 / metabolism*
-
Lymphocyte Activation / physiology
-
Lymphocytes / immunology
-
Lymphocytes / metabolism*
-
Male
-
Matched-Pair Analysis
-
Middle Aged
-
Neuropsychological Tests
-
Severity of Illness Index
-
Statistics as Topic
-
Tumor Necrosis Factor-alpha / metabolism*
Substances
-
Biomarkers
-
Interleukin-1
-
Interleukin-6
-
Tumor Necrosis Factor-alpha
-
Cortisone