Neuropsychological effects of chronic methamphetamine use on neurotransmitters and cognition: a review

J Neuropsychiatry Clin Neurosci. 2003 Summer;15(3):317-25. doi: 10.1176/jnp.15.3.317.


Methamphetamine use is on the rise, with an imminent upsurge of abuse and dependence reported across the United States. Currently, preliminary evidence suggests that methamphetamine dependence may cause long-term neural damage in humans, with concomitant deleterious effects on cognitive processes such as memory and attention. This selective review provides an outline and synthesis of studies that assess the neurotoxic mechanisms of methamphetamine, as well as those that evaluate the cognitive sequelae of methamphetamine abuse.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Central Nervous System Stimulants / adverse effects*
  • Cognition / drug effects*
  • Diagnostic Imaging / methods
  • Dopamine / metabolism
  • Electrophysiology / methods
  • Humans
  • Methamphetamine / adverse effects*
  • Methamphetamine / chemistry
  • Neurotransmitter Agents / metabolism*
  • Serotonin / metabolism
  • Substance-Related Disorders


  • Central Nervous System Stimulants
  • Neurotransmitter Agents
  • Serotonin
  • Methamphetamine
  • Dopamine