Regional cerebral blood flow and cognitive deficits in chronic lyme disease

J Neuropsychiatry Clin Neurosci. Summer 2003;15(3):326-32. doi: 10.1176/jnp.15.3.326.

Abstract

This study examined brain functioning in patients with Lyme encephalopathy. Eleven patients underwent neuropsychological tests and Xenon(133)-regional cerebral blood flow (rCBF) studies, using an external detector system. Each rCBF scan was age- and sex-matched to two archival, normal controls. While few differences were noted on gray-matter flow indices (ISI, fg), Lyme patients demonstrated significant flow reductions in white matter index (k(2)) (p=.004), particularly in the posterior temporal and parietal lobes bilaterally (p=.003). Flow reductions in white matter areas were significantly associated with deficits in memory (r=.66, p=.027) and visuospatial organization (r=.62, p=.041). Results suggest that Lyme encephalopathy may be a disease primarily affecting the cerebral white matter.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain Mapping
  • Case-Control Studies
  • Cerebral Cortex / blood supply*
  • Chronic Disease
  • Cognition Disorders / etiology*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Lyme Disease / physiopathology*
  • Lyme Disease / psychology
  • Magnetic Resonance Imaging / instrumentation
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Regional Blood Flow / physiology
  • Xenon Isotopes / pharmacokinetics

Substances

  • Xenon Isotopes