Prevention of development of tolerance and dependence to opiate in mice by BR-16A (Mentat), a herbal psychotropic preparation

Indian J Exp Biol. 1992 Oct;30(10):885-8.


Chronic treatment with BR-16A (20-500 mg/kg) followed by saline on days 1 to 9 failed to produce any significant change in tail-flick latency from the saline-pretreated group in mice. Repeated administration of BR-16A(20-500 mg/kg) for 9 days however, attenuated the development of tolerance to the analgesic effect of morphine (10 mg/kg). BR-16A (20-500 mg/kg) also suppressed, in a dose-dependent manner, the development of morphine dependence as assessed by naloxone (2 mg/kg)-precipitated withdrawal on day 10 of testing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Dose-Response Relationship, Drug
  • Drug Tolerance
  • Female
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Morphine*
  • Plant Extracts / therapeutic use*
  • Plants, Medicinal
  • Psychotropic Drugs / therapeutic use*
  • Substance Withdrawal Syndrome / drug therapy
  • Substance-Related Disorders / prevention & control*


  • Mentat
  • Plant Extracts
  • Psychotropic Drugs
  • Morphine