Cerebrospinal fluid neopterin and beta 2-microglobulin levels in neurologically asymptomatic HIV-infected patients before and after initiation of zidovudine treatment

L Hagberg; G Norkrans; M Andersson; H Wachter; D Fuchs

doi:10.1007/BF01710672

Cerebrospinal fluid neopterin and beta 2-microglobulin levels in neurologically asymptomatic HIV-infected patients before and after initiation of zidovudine treatment

Infection. 1992 Nov-Dec;20(6):313-5. doi: 10.1007/BF01710672.

Authors

L Hagberg¹, G Norkrans, M Andersson, H Wachter, D Fuchs

Affiliation

¹ Dept. of Infectious Diseases, University of Göteborg, Ostra Hospital, Sweden.

PMID: 1293049
DOI: 10.1007/BF01710672

Abstract

The effect of zidovudine on beta 2-microglobulin and neopterin in the cerebrospinal fluid (CSF) was studied in ten HIV-seropositive neurologically healthy individuals. CSF concentrations of neopterin decreased by 53% (from 20.3 to 9.5 nmol/l, p < 0.01) and beta 2-microglobulin by 36% (from 2.8 to 1.8 mg/l, p < 0.01) four to eight months after initiation of therapy.

MeSH terms

Biopterins / analogs & derivatives*
Biopterins / cerebrospinal fluid
HIV Infections / cerebrospinal fluid
HIV Infections / drug therapy*
Humans
Neopterin
Zidovudine / therapeutic use*
beta 2-Microglobulin / cerebrospinal fluid*

Substances

beta 2-Microglobulin
Biopterins
Zidovudine
Neopterin