Comparison of the effects of sevoflurane and total intravenous anaesthesia in percutaneous nephrolithotomy

Eur J Anaesthesiol. 2003 Aug;20(8):653-7. doi: 10.1017/s0265021503001054.


Background and objective: Although percutaneous nephrolithotomy has many advantages over open surgery, some endocrine and haemodynamic responses have been reported. However, the effects of anaesthetic agents on these responses have not previously been reported. This study compared the effects of sevoflurane and total intravenous anaesthesia using propofol and alfentanil on the haemodynamic and hormonal changes during percutaneous nephrolithotomy.

Methods: Forty-two ASA I-II patients aged between 15 and 65 yr were studied. Sevoflurane in Group S (21 patients) or TIVA in Group TIVA (21) was used for the maintenance of anaesthesia. Haemodynamic variables and serum concentrations of sodium and potassium were measured before, during and after the procedure. Arterial blood-gas status, plasma renin, aldosterone and adrenocorticotrophic hormone concentrations were measured before and during the procedure.

Results: Mean heart rate was lower during percutaneous nephrolithotomy in Group TIVA compared with Group S (P < 0.01). The mean systolic and diastolic arterial pressures were not different in both groups at any stage of measurement (P < 0.05). Plasma renin, aldosterone and adrenocorticotrophic hormone concentrations were increased during percutaneous nephrolithotomy in both groups, but the increase was greater in Group S (P < 0.05).

Conclusions: In the sevoflurane group, the concentrations of renin, aldosterone and adrenocorticotrophic hormone were significantly higher after 15 min of irrigation compared with the total intravenous anaesthesia group. Although the clinical significance of this difference was not clear, these changes should be considered in certain patient groups.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Alfentanil / blood
  • Alfentanil / pharmacology
  • Anesthesia, Intravenous*
  • Anesthetics, Combined / blood
  • Anesthetics, Combined / pharmacology
  • Anesthetics, Inhalation / blood
  • Anesthetics, Inhalation / pharmacology*
  • Bicarbonates / blood
  • Blood Pressure / drug effects
  • Female
  • Heart Rate / drug effects
  • Hormones / blood
  • Humans
  • Hydrogen-Ion Concentration / drug effects
  • Male
  • Methyl Ethers / blood
  • Methyl Ethers / pharmacology*
  • Middle Aged
  • Nephrostomy, Percutaneous*
  • Propofol / blood
  • Propofol / pharmacology
  • Sevoflurane
  • Sodium / blood


  • Anesthetics, Combined
  • Anesthetics, Inhalation
  • Bicarbonates
  • Hormones
  • Methyl Ethers
  • Alfentanil
  • Sevoflurane
  • Sodium
  • Propofol