Eudesmane derivatives and other sesquiterpenes from Laggera alata

J Nat Prod. 2003 Aug;66(8):1078-81. doi: 10.1021/np0205856.

Abstract

Three new eudesmane sesquiterpenes, 5 beta-hydroxyilicic acid (1), 5 alpha-hydroxyl-4-epi-ilicic acid methyl ester (2), and 3 alpha-hydroxyilicic acid (3), together with 12 known sesquiterpenes were isolated from the aerial part of Laggera alata. Their structures were elucidated primarily by NMR and mass spectroscopic methods. The structures of 1 and 2 were confirmed by X-ray crystallography.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asteraceae / chemistry*
  • Crystallography, X-Ray
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Humans
  • Inhibitory Concentration 50
  • KB Cells / drug effects
  • Lung Neoplasms
  • Melanoma
  • Molecular Conformation
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Sesquiterpenes, Eudesmane / chemistry
  • Sesquiterpenes, Eudesmane / isolation & purification*
  • Sesquiterpenes, Eudesmane / pharmacology
  • Stereoisomerism
  • Tumor Cells, Cultured / drug effects

Substances

  • 3alpha-hydroxyilicic acid
  • 5 beta-hydroxyilicic acid
  • 5alpha-hydroxyl-4-epi-ilicic acid methyl ester
  • Drugs, Chinese Herbal
  • Sesquiterpenes, Eudesmane