Molecular phylogeny within type I cytokines and their cognate receptors

Immunity. 2003 Aug;19(2):159-63. doi: 10.1016/s1074-7613(03)00211-5.

Abstract

Type I helical cytokines are ligands for receptors structurally related by a common sequence signature. Here we analyze the 27 ligands and 34 human type I cytokine receptor encoded by the human genome. We compare these to ligands and receptors found in mouse and insects. We describe their structural relatedness to one another and discuss the evolution of these gene families.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Anopheles / genetics
  • Anopheles / immunology
  • Cytokines / classification
  • Cytokines / genetics*
  • Cytokines / metabolism
  • Drosophila / genetics
  • Drosophila / immunology
  • Evolution, Molecular
  • Humans
  • Mice
  • Multigene Family
  • Phylogeny
  • Protein-Tyrosine Kinases / metabolism
  • Receptors, Cytokine / genetics*
  • Receptors, Cytokine / metabolism
  • Signal Transduction
  • Species Specificity
  • Transcription Factors / metabolism

Substances

  • Cytokines
  • Receptors, Cytokine
  • Transcription Factors
  • Protein-Tyrosine Kinases