[Relationship between Ala98Val variant of hepatocyte nuclear factor-1 alpha gene and late-onset type 2 diabetes in Han nationality]

Hunan Yi Ke Da Xue Xue Bao. 2003 Apr;28(2):93-4.
[Article in Chinese]

Abstract

Objective: To ascertain whether Ala98Val variant in exon 1 of hepatocyte nuclear factor-1 alpha (HNF-1 alpha) gene is associated with late-onset Type 2 diabetes in Chinese Han nationality.

Methods: We selected 150 patients with late-onset Type 2 diabetes and 155 controls, and detected Ala98Val variant with polymerase chain reaction-single strand conformational polymorphism(PCR-SSCP) and direct sequencing.

Results: None of Ala98Val variant was found in all of the subjects.

Conclusion: The Ala98Val variant doesn't play an important role in late-onset Type 2 diabetes in Chinese Han nationality.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Alanine / genetics
  • Amino Acid Substitution
  • Asian Continental Ancestry Group
  • DNA-Binding Proteins / genetics*
  • Diabetes Mellitus, Type 2 / genetics*
  • Ethnic Groups
  • Female
  • Genetic Variation*
  • Hepatocyte Nuclear Factor 1
  • Hepatocyte Nuclear Factor 1-alpha
  • Humans
  • Male
  • Middle Aged
  • Nuclear Proteins / genetics*
  • Polymerase Chain Reaction
  • Polymorphism, Single-Stranded Conformational
  • Sequence Analysis, DNA
  • Transcription Factors / genetics*

Substances

  • DNA-Binding Proteins
  • HNF1A protein, human
  • Hepatocyte Nuclear Factor 1-alpha
  • Nuclear Proteins
  • Transcription Factors
  • Hepatocyte Nuclear Factor 1
  • Alanine