Abstract
The triple-base-pair 16S rDNA mutation AGA(926-928)-->TTC mediates high-level tetracycline resistance in Helicobacter pylori. In contrast, single- and double-base-pair mutations mediated only low-level tetracycline resistance and decreased growth rates in the presence of tetracycline, explaining the preference for the TTC mutation in tetracycline-resistant H. pylori isolates.
MeSH terms
-
Cloning, Molecular
-
DNA Primers
-
Helicobacter pylori / drug effects*
-
Helicobacter pylori / genetics*
-
Helicobacter pylori / growth & development
-
Mutagenesis, Site-Directed
-
Mutation / genetics*
-
Mutation / physiology*
-
RNA, Ribosomal, 16S / genetics*
-
Reverse Transcriptase Polymerase Chain Reaction
-
Tetracycline Resistance / genetics*
-
Tetracycline Resistance / physiology*
Substances
-
DNA Primers
-
RNA, Ribosomal, 16S