Novel Pseudomonas aeruginosa gene that suppresses tolerance to carbapenems

Antimicrob Agents Chemother. 2003 Sep;47(9):2997-3001. doi: 10.1128/AAC.47.9.2997-3001.2003.

Abstract

A biapenem-tolerant mutant of Pseudomonas aeruginosa was isolated by Tn1737KH insertion. The survival of the mutant 3 h after the addition of biapenem was about 1000 times greater than that of the wild type. The mutant was also tolerant to other biapenems, such as imipenem, panipenem, and meropenem.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carbapenems / pharmacology*
  • Colony Count, Microbial
  • DNA Primers
  • DNA Transposable Elements / genetics
  • Drug Resistance, Bacterial / genetics
  • Mice
  • Mice, Knockout
  • Microbial Sensitivity Tests
  • Plasmids / genetics
  • Pseudomonas aeruginosa / genetics*

Substances

  • Carbapenems
  • DNA Primers
  • DNA Transposable Elements